The Clear Skin Project Blog

Pros & Cons of Using Antibiotics For Acne Treatment

Causes of Acne
Causes of Acne

While once thought to be successful acne treatments solely for reducing P. acnes bacteria, the anti-inflammatory properties of antibiotics have proven to be much more effective. In a recent article in The Conversation, Dr. Adam Friedman, Associate Professor of Dermatology at George Washington University, explains that antibiotics, such as doxycycline and minocycline, inhibit the production of pro-inflammatory signaling molecules that drive the inflammation behind acne.

Despite their success reducing inflammation, antibiotics must be used with caution. Antibiotics have a history of being prescribed at higher doses and longer durations than necessary to kill P. acnes and reduce inflammation, leading to the development of antibiotic resistant bacteria. Dr. Friedman mentions that sub-antibacterial doses of antibiotics (doses that are too low to kill bacteria) still have anti-inflammatory effects without killing good bacteria or causing resistance in pathogenic bacteria. He also references professional treatment guidelines which always recommend combining antibiotics with nonantibiotic topical treatments such as benzoyl peroxide or retinoids.

Future treatments that are currently in trial will focus on agents that kill P. acnes or reduce inflammation without leading to microbial resistance. Promising solutions include using synthetic antimicrobial peptides to destroy P. acnes or using nitric oxide to both kill P. acnes and reduce inflammation.Roblox Robux Hack 2017

In the meantime, Dr. Friedman recommends that acne patients work closely with their dermatologists to manage the proper dosing and duration of antibiotic treatments.

For more detailed information, check out the full article:

Rosacea: The Latest News In Topical Treatment

hqdefaultIn a recent study on papulopustular rosacea, Dermatologist Hilary Baldwin, M.D., Medical Director at the Acne Treatment and Research Center and a Galderma consultant, tells Dermatology Times that new data showing longer time to relapse and more days free of medication for patients successfully treated with once daily Soolantra Cream versus those treated with twice daily metronidazole addresses “real world” human nature.

“Knowing that rosacea is a chronic condition, long-term suppression of the inflammatory process is to the benefit of the patient,” Dr. Baldwin says. “So I always encourage my patients to remain on their treatment, even when their symptoms improve — reminding them it is not about how they look tomorrow, or a week from now, but five or 10 years down the road. However, we know in real-world practice, patients aren’t always going to remain compliant in drug application, especially when their symptoms are better. Based on the findings of the long term phase 3 ATTRACT study, the benefit of using Soolantra Cream is that it extends remission longer than metronidazole, giving patients the opportunity to take a ‘drug holiday’ from their prescription, without necessarily losing any progress with their treatment.”

Dr. Baldwin says that she anticipated using ivermectin 1% cream as an adjunctive therapy to Oracea (doxycycline, USP 40 mg, Galderma) for patients with severe papulopustular rosacea. However, while she often uses the medications together, she now also uses Soolantra Cream as a standalone treatment with positive results. “Therefore, now I often let the patient decide between an oral or topical treatment, given the strong safety and efficacy profiles seen in both Oracea and Soolantra. I find that if the patient is part of the decision, they tend to have better compliance with their medication,” she says.

According to Dr. Baldwin, anyone with papulopustular rosacea is an eligible candidate for Soolantra Cream, regardless of severity. “Mild, moderate or severe, Soolantra works well to reduce inflammatory lesions — though not studied in erythematotelangiectatic rosacea. Patients with really sensitive skin, or those who do not like to take oral medications, are very good candidates for Soolantra Cream,” Dr. Baldwin says.

Dr. Baldwin says that she has not heard any patients in her practice complain of side effects from the Soolantra cream. “In fact, Soolantra Cream was specifically designed to be gentle on the skin, using Cetaphil as the basis for the vehicle, which is important to rosacea patients who often have sensitive skin,” she says. “In clinical trials, side effects were infrequent and mild, with the most common including skin burning sensation and skin irritation. Proper use of any prescription treatment is critical in managing side effects.”

For more information on the study, please visit:


Volunteers Needed for Research Study – New York City

imagetempalte_8_250x250_acf_croppedIcahn School of Medicine at Mt. Sinai is seeking volunteers for two studies related to acne research. You do not need insurance to participate.

You may be eligible if:
– You are 18+ years of age and under the age of 35 years and HAVE NOT been diagnosed with acne.
– You HAVE NOT participated in any clinical trial in the past 60 days.


– You are 18+ years of age and under the age of 35 years and HAVE been diagnosed with moderate to severe acne.
– You HAVE NOT participated in any clinical trial in the past 60 days.
– You are not currently taking isotretinoin for not less than 12 months.
– You are not currently on acne medications, including topical or oral medications, or light or laser therapies, including at-home devices.

Qualified participants will receive:
– Study-related medical exams at no cost
– $250 compensation for time and travel

Note: Study requires one visit that will last approximately 1 hour.

Call 212-241-6033 for more information.