While once thought to be successful acne treatments solely for reducing P. acnes bacteria, the anti-inflammatory properties of antibiotics have proven to be much more effective. In a recent article in The Conversation, Dr. Adam Friedman, Associate Professor of Dermatology at George Washington University, explains that antibiotics, such as doxycycline and minocycline, inhibit the production of pro-inflammatory signaling molecules that drive the inflammation behind acne.
Despite their success reducing inflammation, antibiotics must be used with caution. Antibiotics have a history of being prescribed at higher doses and longer durations than necessary to kill P. acnes and reduce inflammation, leading to the development of antibiotic resistant bacteria. Dr. Friedman mentions that sub-antibacterial doses of antibiotics (doses that are too low to kill bacteria) still have anti-inflammatory effects without killing good bacteria or causing resistance in pathogenic bacteria. He also references professional treatment guidelines which always recommend combining antibiotics with nonantibiotic topical treatments such as benzoyl peroxide or retinoids.
Future treatments that are currently in trial will focus on agents that kill P. acnes or reduce inflammation without leading to microbial resistance. Promising solutions include using synthetic antimicrobial peptides to destroy P. acnes or using nitric oxide to both kill P. acnes and reduce inflammation.Roblox Robux Hack 2017
In the meantime, Dr. Friedman recommends that acne patients work closely with their dermatologists to manage the proper dosing and duration of antibiotic treatments.
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